Drawing primarily from data and experience from large-scale microbicide efficacy trials, this article published in the Journal of the International AIDS Society identifies lessons learned about adherence to study regimens in six areas: 1) adherence measurement in clinical trials, 2) comprehension of use instructions/instructions for use, 3) unknown efficacy and its effect on adherence/messages regarding effectiveness, 4) partner influence on use, 5) retention and continuation, and 6) the generalizability of trial participants' adherence behavior.

AVAC's fact sheet explains some of the main statistical terms used to describe the results of clinical trials, including statistical significance, confidence interval, and intent-to-treat analysis.

This 88-page document outlines good participatory practice (GPP) guidelines and systematic guidance on how trial funders, sponsors, and implementers can effectively engage with all stakeholders in the design and conduct of biomedical HIV prevention trials. The GPP guidelines are divided into three main sections: the importance of and need for GPP in biomedical HIV prevention trials, guiding principles of GPP, and optimal GPP practices for biomedical HIV prevention trials.

Using case studies and practical insights culled from communications experience in clinical trials from around the world, this handbook covers the spectrum of communications planning, strategies, and activities needed at each stage of a clinical trial. It offers practical guidance to clinical trial staff and research partners on how to anticipate and respond to the special communication challenges posed by the conduct of clinical research. First published in 2010, the handbook is now available online with additional resources, including videos, slide presentations and new case studies.