Dapivirine

  • The Ring Study

    This page on the website of the International Partnership for Microbicides (IPM) provides information and links to resources about The Ring Study, a clinical trial designed to determine whether a monthly vaginal ring that delivers the antiretroviral drug dapivirine helps prevent HIV infection in women and is safe for long-term use. The Ring Study, which enrolled 1,959 women at six sites in South Africa and one site in Uganda, was one of two trials of the dapivirine ring to demonstrate a protective effect against HIV.

  • ASPIRE – MTN 020

    Links are provided to information about ASPIRE (A Study to Prevent Infection with a Ring for Extended Use), a Phase III safety and effectiveness trial of a vaginal ring containing the antiretroviral drug dapivirine that enrolled 2,629 women at several sites in Africa and was one of two trials of this monthly ring to demonstrate a protective effect against HIV infection.

  • A Multipurpose Prevention Ring for Women's Sexual and Reproductive Health

    This fact sheet addresses the need for multipurpose prevention technologies and describes an MPT that the International Partnership for Microbicides is testing, a vaginal ring that contains the antiretroviral drug dapivirine and the contraceptive hormone levonorgestrel.

  • ASPIRE and The Ring Study Results – A Snapshot

    The results of two randomized clinical trials of the use of a dapivirine vaginal ring for HIV prevention, A Study to Prevent Infection with a Ring for Extended Use (ASPIRE) and The Ring Study, are summarized in a table.

  • Use of a Vaginal Ring Containing Dapivirine for HIV-1 Prevention in Women

    Published in the New England Journal of Medicine on December 1, 2016, this article reports on the results of A Study to Prevent Infection with a Ring for Extended Use (ASPIRE). The authors conclude that a monthly vaginal ring containing dapivirine reduced the risk of HIV-1 infection among African women, with increased efficacy among subgroups of the study population with evidence of more consistent use of the ring.

  • Video: Microbicides — Developing New HIV Prevention Options for Women

    A monthly vaginal ring that releases a drug for HIV prevention has been shown to safely help reduce the risk of infection and could give women a novel way to protect themselves. This video describes the latest research and the next steps for the dapivirine ring.

  • Sister Studies: The Ring Study and ASPIRE

    The Ring Study and ASPIRE (A Study to Prevent Infection with a Ring for Extended Use) are described in this fact sheet. The two related trials showed that monthly use of a vaginal ring that delivers the antiretroviral drug dapivirine can help prevent HIV infection in women and is safe for long-term use.

  • IPM Clinical Trials

    This regularly updated resource includes a list of all the International Partnership for Microbicides’ ongoing and planned trials of dapivirine in the form of a ring, a tablet, and a ring combining dapivirine with maraviroc, another antiretroviral drug.