The Microbicide Trials Network (MTN), in partnership with AVAC, held a consultation with key stakeholders in Johannesburg, South Africa, from April 5–6, 2018, to hear their views about the design and objectives of the MTN–042 study and to seek their opinions about specific aspects of the study. Held as part of the protocol development process, the consultation was timed so that stakeholder feedback could then be considered at a meeting of the team developing the MTN–042 study protocol.