HIV prevention research

  • Assessing the Potential of MPTs in South Africa, Uganda and Nigeria

    Market research conducted by Ipsos with support from the Bill & Melinda Gates Foundations assessed the acceptability of multipurpose prevention technologies (MPTs) among women in South Africa, Uganda, and Nigeria, focusing on four potential MPTs: injectables, implants, intravaginal film, and intravaginal rings. This webpage provides links to a booklet about the study, regional maps, and a summary of the quantitative results and their implications.

  • Setting the Stage for ARV-Based Prevention for Women: A Snapshot of the Zimbabwean Context

    A program brief summarizes the findings of a landscape analysis conducted in Zimbabwe as part of a process developed by the Population Council to help policymakers and program managers identify the most strategic opportunities for introducing tenofovir gel. Based on a desk review and interviews with key decision makers, the brief reviews the epidemiologic context of the HIV epidemic, highlights policies and programs related to HIV, and provides other information relevant to potential introduction of tenofovir vaginal gel in Zimbabwe.

  • Program and Policy Considerations for Tenofovir Gel in India

    A program brief summarizes the findings of a landscape analysis conducted in India as part of a process developed by the Population Council to help policymakers and program managers identify the most strategic opportunities for introducing tenofovir gel. Based on a desk review and interviews with key decision makers, the brief reviews the epidemiologic context of the HIV epidemic, highlights policies and programs related to HIV, and provides other information relevant to potential introduction of tenofovir vaginal gel in India.

  • An Interdisciplinary Framework for Measuring and Supporting Adherence in HIV Prevention Trials of ARV-Based Vaginal Rings

    Correct, consistent use of study products and measurement of adherence to study regimens have emerged as critical challenges in the evaluation of HIV prevention technologies. This article, published in a September 2014 supplement to the Journal of the International AIDS Society, presents an interdisciplinary framework for systematically investigating promising strategies to support product uptake and adherence and to measure adherence in randomized, blinded clinical trials of antiretroviral-based vaginal rings.

  • Microbicide Clinical Trial Adherence: Insights for Introduction

    Drawing primarily from data and experience from large-scale microbicide efficacy trials, this article published in the Journal of the International AIDS Society identifies lessons learned about adherence to study regimens in six areas: 1) adherence measurement in clinical trials, 2) comprehension of use instructions/instructions for use, 3) unknown efficacy and its effect on adherence/messages regarding effectiveness, 4) partner influence on use, 5) retention and continuation, and 6) the generalizability of trial participants' adherence behavior.

  • A Toolkit for Developing Bilingual Lexicons for International HIV Prevention Clinical Trials

    Researchers often use technical terminology that trial participants may not easily understand. Those working on international clinical trials face additional communication challenges when local languages do not have scientific or technical vocabularies in relevant subject areas. This toolkit guides researchers through a process for identifying or improving translations of clinical research terms that are difficult to translate or comprehend.

  • Advocates' Guide to Statistical Terms

    AVAC's fact sheet explains some of the main statistical terms used to describe the results of clinical trials, including statistical significance, confidence interval, and intent-to-treat analysis.

  • Preparing for Rectal Microbicides: Sociocultural Factors Affecting Product Uptake Among Potential South American Users

    Published in the June 2014 issue of the American Journal of Public Health, this article reports on the results of a qualitative study conducted among 140 men who have sex with men and transgender women in Lima and Iquitos, Peru, and Guayaquil, Ecuador, to explore their views on rectal microbicides and identify factors that could affect uptake of a rectal microbicide.

     

     

  • When Do You Stop an HIV Prevention Trial for Futility? A Primer for HIV Prevention Advocates

    This fact sheet examines why trials are stopped early for “futility,” explaining the meaning of this term in the context of a clinical trial, when such a recommendation is made, and how it might affect other trials.

  • Understanding HIV Drug Resistance in the Context of Microbicides and Pre-Exposure Prophylaxis (PrEP)

    This clear and accessible two-page fact sheet explains the basic concept of HIV drug resistance and how it occurs by posing and answering four key questions. The document includes simple, illustrative diagrams and a summary of important points to remember.

Pages