Microbicides

  • Assessing Physical Delivery of PrEP in Support of Proof of Deliverability: Results from Kenya

    The findings from an assessment of the feasibility and potential impact of delivering antiretroviral (ARV)-based oral and injectable pre-exposure prophylaxis (PrEP) and vaginal microbicide gels in Kenya are summarized in this brief.

  • Perspectives on Use of Oral and Vaginal Antiretrovirals for HIV Prevention: the VOICE-C Qualitative Study in Johannesburg, South Africa

    The VOICE trial of tenofovir-based vaginal gel and pills was unable to demonstrate efficacy for HIV prevention because of low adherence to study regimens. This study, published in a September 2014 supplement to the Journal of the International AIDS Society, explores views of and experiences with the use of antiretrovirals for HIV prevention among VOICE participants, their male partners, and community members and examines the implications for adherence.

  • Microbicide Clinical Trial Adherence: Insights for Introduction

    Drawing primarily from data and experience from large-scale microbicide efficacy trials, this article published in the Journal of the International AIDS Society identifies lessons learned about adherence to study regimens in six areas: 1) adherence measurement in clinical trials, 2) comprehension of use instructions/instructions for use, 3) unknown efficacy and its effect on adherence/messages regarding effectiveness, 4) partner influence on use, 5) retention and continuation, and 6) the generalizability of trial participants' adherence behavior.

  • Cost-effectiveness of Tenofovir Gel in Urban South Africa: Model Projections of HIV Impact and Threshold Product Prices

    Published in BMJ Infectious Diseases, this article reports on a modeling study that used the results of the CAPRISA 004 trial of tenofovir gel to estimate the population-level impact of the gel on HIV and HSV-2 transmission and the price thresholds at which widespread product introduction would be as cost-effective as male circumcision for HIV prevention in urban South Africa.

     

  • Preparing for Rectal Microbicides: Sociocultural Factors Affecting Product Uptake Among Potential South American Users

    Published in the June 2014 issue of the American Journal of Public Health, this article reports on the results of a qualitative study conducted among 140 men who have sex with men and transgender women in Lima and Iquitos, Peru, and Guayaquil, Ecuador, to explore their views on rectal microbicides and identify factors that could affect uptake of a rectal microbicide.

     

     

  • Communicating About Microbicides with Women in Mind (fact sheet)

    The Communicating about Microbicides with Women in Mind project developed a two-page document highlighting the project’s major accomplishments, including details about the three project phases conducted in Kenya: 1) the landscape analysis, 2) the materials development and pretesting, and 3) the materials assessment and key results.

  • Communicating about Microbicides with Women in Mind: Communication Strategy and Adaptation Guide

    This final report for the Communicating about Microbicides with Women in Mind project was written to: 1) document the promise of vaginal microbicide gel as a new HIV prevention product for women, 2) describe the project’s experience with materials development, 3) provide a sample microbicide communication strategy for Kenya and 4) outline a process for updating and adapting the materials for use in other countries or with other new HIV prevention methods.

  • Findings from a Gender Analysis for Microbicide Introduction in South Africa

    FHI 360 and Sonke Gender Justice conducted a gender analysis for microbicide introduction in South Africa. The process included a desk review, interviews with key stakeholders, and an interpretation meeting to identify gender norms and inequalities that increase women’s HIV risk and could inhibit women’s access and adherence to microbicides in the future. This brief outlines 11 strategies that could be part of a microbicide introduction program to overcome these gender-related barriers.

  • A Pocket Guide to Thinking about Gender & Vaginal Microbicides in South Africa

    FHI 360 and Sonke Gender Justice conducted a gender analysis in South Africa to identify gender-related barriers and opportunities to women’s microbicide access and use and to make recommendations for addressing those barriers. This pocket card, created with input from the South African National AIDS Council (SANAC) Men’s and Women’s sectors, is designed to build support for a gender-integrated microbicides rollout among community members and policy makers.

  • HIV Prevention for Women in Kenya: An Advocacy Guide for Gender-Sensitive Microbicide Introduction

    Based on findings from a gender analysis in Kenya, these advocacy tools can be used to raise awareness of key gender issues that need to be addressed in planning for microbicide introduction in Kenya. The guide includes: (1) a summary of gender issues that will affect women’s microbicide access and use; (2) guidance for policymakers and program designers on developing a gender-transformative microbicide introduction program; and (3) three case studies that nongovernmental organizations and other advocates in the community can use to generate discussion about microbicides.

Pages