Vaginal Ring

  • The Ring Study

    This page on the website of the International Partnership for Microbicides (IPM) provides information and links to resources about The Ring Study, a clinical trial designed to determine whether a monthly vaginal ring that delivers the antiretroviral drug dapivirine helps prevent HIV infection in women and is safe for long-term use. The Ring Study, which enrolled 1,959 women at six sites in South Africa and one site in Uganda, was one of two trials of the dapivirine ring to demonstrate a protective effect against HIV.

  • ASPIRE – MTN 020

    Links are provided to information about ASPIRE (A Study to Prevent Infection with a Ring for Extended Use), a Phase III safety and effectiveness trial of a vaginal ring containing the antiretroviral drug dapivirine that enrolled 2,629 women at several sites in Africa and was one of two trials of this monthly ring to demonstrate a protective effect against HIV infection.

  • The Promise of the Ring for Women’s HIV Prevention

    Watch this video to learn about the dapivirine vaginal ring and the International Partnership for Microbicide’s next steps to potentially put the product into the hands of women at high risk of HIV.

  • Safety and Efficacy of a Dapivirine Vaginal Ring for HIV Prevention in Women

    The results of The Ring Study, a randomized controlled trial that evaluated the safety and efficacy of extended use of a vaginal ring containing dapivirine for the prevention of HIV infection among women in South Africa and Uganda,were published December 1, 2016, in The New England Journal of Medicine. The authors concluded that the dapivirine ring was not associated with any safety concerns and was associated with a rate of acquisition of HIV-1 infection that was lower than the rate with placebo.

  • A Multipurpose Prevention Ring for Women's Sexual and Reproductive Health

    This fact sheet addresses the need for multipurpose prevention technologies and describes an MPT that the International Partnership for Microbicides is testing, a vaginal ring that contains the antiretroviral drug dapivirine and the contraceptive hormone levonorgestrel.

  • Use of a Vaginal Ring Containing Dapivirine for HIV-1 Prevention in Women

    Published in the New England Journal of Medicine on December 1, 2016, this article reports on the results of A Study to Prevent Infection with a Ring for Extended Use (ASPIRE). The authors conclude that a monthly vaginal ring containing dapivirine reduced the risk of HIV-1 infection among African women, with increased efficacy among subgroups of the study population with evidence of more consistent use of the ring.

  • FACTS 001 Trial: Questions and Answers

    Questions and answers about the FACTS 001 efficacy trial of the use of tenofovir vaginal gel among women in South Africa provide background on the study and information about its results and their implications.

  • Video: Microbicides — Developing New HIV Prevention Options for Women

    A monthly vaginal ring that releases a drug for HIV prevention has been shown to safely help reduce the risk of infection and could give women a novel way to protect themselves. This video describes the latest research and the next steps for the dapivirine ring.

  • Shaping the Operations Research Agenda for Antiretroviral-Based Prevention Products for Women: Gels and Rings

    In 2012 the Population Council organized a consultation on an operations research agenda as part of a larger initiative, funded by the US Agency for International Development, to prepare for microbicide introduction. The consultation report outlines the ideas the 40 participants generated for priority research topics and approaches.

  • An Interdisciplinary Framework for Measuring and Supporting Adherence in HIV Prevention Trials of ARV-Based Vaginal Rings

    Correct, consistent use of study products and measurement of adherence to study regimens have emerged as critical challenges in the evaluation of HIV prevention technologies. This article, published in a September 2014 supplement to the Journal of the International AIDS Society, presents an interdisciplinary framework for systematically investigating promising strategies to support product uptake and adherence and to measure adherence in randomized, blinded clinical trials of antiretroviral-based vaginal rings.

Pages