This report is based on a review of peer-reviewed articles, collaborative guidance and recommendations, and grey literature which examined the sexual and reproductive health and rights and needs of female sex workers. The first section of this report aims to provide an overview of best practices around the SRHR of FSWs, including those related to HIV/AIDS, family planning, sexual health, maternal health, and gender-based violence, as well as highlight some of the most urgent knowledge gaps that should be addressed moving forward. The second section of this report assesses how U.S. foreign assistance can better conform with best practices to support the SRHR of FSWs, including both specific policies and more general programmatic approaches.