Described as the foundation upon which the Global Health Initiative (GHI) rests, the President’s Emergency Plan for AIDS Relief (PEPFAR) is undergoing significant change. HIV/AIDS prevention, care and treatment remain the focus of PEPFAR, yet the GHI mandates that PEPFAR—along with the rest of the U.S. government’s global health portfolio—take a more holistic approach to meeting individuals’ primary and preventive health care needs, especially for women and girls, with family planning/reproductive health chief among those.The purpose of this unofficial guide is to clarify current U.S. policy regarding the integration of family planning/ reproductive health, maternal and child health, and HIV/AIDS within U.S. global health assistance.