Links to press statements, fact sheets, and other information about the VOICE (Vaginal and Oral Interventions to Control the Epidemic) trial conducted by the Microbicide Trials Network are provided on this page. VOICE evaluated the safety and effectiveness of three antiretroviral-based approaches for preventing sexual transmission of HIV in women: applying tenofovir gel daily or taking an antiretroviral tablet (tenofovir or Truvada) once a day. None of these approaches proved to be effective among the 5,029 women enrolled in the trial. The results showed that most of the participants did not use the study products daily as directed.