The Need

Vaginal microbicides will give more power to women who have trouble negotiating condom use with their partners or who otherwise need a prevention option that can be used discreetly. Because the risk of HIV infection is up to 20 times higher during unprotected anal intercourse than during unprotected vaginal intercourse, rectal microbicides will be an important prevention option both for women who engage in anal intercourse and for men who have sex with men.