The implementation of a microbicide strategy will require guidance and coordination from normative bodies, such as the World Health Organization and the Joint United Nations Programme on HIV/AIDS, as well as consultations with governments and other stakeholders. Each microbicide will need approval from national regulatory agencies, such as the Food and Drug Administration in the United States or the Medicines Control Council in South Africa, wherever the strategy will be implemented. All of these efforts must be coordinated with national policies and strategies on the introduction of new HIV prevention technologies.